some research highlights...
Scutoids are a Geometrical Solution to 3D Packing of Epithelia, P. Gómez-Gálvez, P. Vicente-Munuera, A. Tagua, C. Forja, A.M. Castro, M. Letrán, A. Valencia-Expósito, C. Grima, M. Bermúdez-Gallardo, Ó. Serrano-Pérez-Higueras, F. Cavodeassi, S. Sotillos, M.D. Martín-Bermudo, A. Márquez, J. Buceta*, and L.M. Escudero*, Nature Communications 9, 2018.
Mechanical Coordination is Sufficient to Promote Tissue Replacement During Metamorphosis in Drosophila, C. Prat-Rojo, P-A. Pouille, J. Buceta, and E. Martin-Blanco*, EMBO J. 39, 2020.
Self-sustained Planar Intercalations due to Mechanosignaling Feedbacks Lead to Robust Axis Extension during Morphogenesis, S. Anbari and J. Buceta*, Scientific Reports 10, 2020.
The complex 3D organization of Epithelial Tissues, P. Gómez-Gálvez, P. Vicente-Munuera, S. Anbari, J. Buceta*, and L.M. Escudero*, Development 148, 2021.
A Quantitative Biophysical Principle to Explain the 3D Cellular Connectivity in Curved Epithelia, P. Gómez-Gálvez*, P. Vicente-Munuera, S. Anbari, A. Tagua, C. Gordillo-Vázquez, J. A. Andres-San Roman, D. Franco-Barranco, A.M. Palacios, A. Velasco,C. Capitan-Agudo, C. Grima, V. Annese, I. Arganda-Carreras, R. Robles, A. Marquez, J. Buceta*, and L.M. Escudero*, Cell Systems 13, 2022.
Comprehensive profiling of neutralizing polyclonal sera targeting coxsackievirus B3, B. Álvarez-Rodríguez*, J. Buceta*, and R. Geller*, Nature Communications 14, 2023.
Apico-basal intercalations enable the integrity or curved epithelia, S. Anbari, P. Gómez-Gálvez, P. Vicente-Munuera, L.M. Escudero* , and J. Buceta*, Computational and Structural Biotechnology J. 27, 2025.
E. coli filament buckling modulates Min patterning and cell division, M. Nadal, L. Guitou, I. Diez, J. Hurtado, A. Mártinez, I. Grobas*, and J. Buceta*, Nature Communications 16, 2025.
The growth project...and muons...
We are interested in understanding the problem of growth and size/shape homeostasis in biology. This topic includes the regulation of size at the cellular level. Questions of interest are, how do cells control their size to achieve homeostasis?, what is the interplay between mechanical cues and gene regulation to trigger division?, At the collective level we are trying to elucidate, and formalize, the mechanisms shaping tissues. Questions of interest include, what are the mechanisms to reliably achieve the elongation of tissues?, how do cell pack together in a 3d space?,
We are also interested in the effect of radiation in bacteria. In particular, we want to understand how muons modulate adaptability and mutagenesis. For this project we collaborate with the LSC underground facility and I was selected for the 2024-2025 NASA Star Program.
Our research has been highlighted by media and popular culture. In particular, the discovery of scutoids has attracted a lot of attention, e.g. Colbert's late show, Meyers' late night, FoX, ABC, NPR, or The New Yorker. A full publication list can be found here.
Buceta’s Lab